Products
Products
Products
| HS Code | 442718 |
| Chemical Name | Isopropyl Alcohol |
| Cas Number | 67-63-0 |
| Molecular Formula | C3H8O |
| Molar Mass | 60.10 g/mol |
| Purity | 99.9% |
| Grade | ACS Reagent Grade |
| Appearance | Clear colorless liquid |
| Odor | Characteristic alcohol-like odor |
| Boiling Point | 82.5 °C |
| Melting Point | -89.5 °C |
| Flash Point | 11.7 °C (closed cup) |
| Density | 0.786 g/cm3 at 20 °C |
| Solubility In Water | Miscible |
| Refractive Index | 1.3776 at 20 °C |
| Vapor Pressure | 44 mmHg at 20 °C |
| Vapor Density | 2.07 (vs air) |
| Autoignition Temperature | 399 °C |
As an accredited Isopropyl Alcohol 99.9% ACS Reagent Grade factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500mL amber glass bottle with leak-proof cap, labeled with hazard warnings, ensuring purity and safe handling for laboratory use. |
| Container Loading (20′ FCL) | Isopropyl Alcohol 99.9% ACS Reagent Grade loaded in a 20' FCL as palletized drums, secured, labeled, and ventilated for safe transport. |
| Shipping | Isopropyl Alcohol 99.9% (ACS Reagent Grade) is a flammable liquid (Class 3) and requires proper hazardous materials shipping. It must be packaged in approved containers, labeled with flammable liquid warnings, and transported with a shipping paper declaring UN1219. Ensure segregation from oxidizers and ignition sources. |
| Storage | Store in tightly sealed, original or compatible containers in a cool, dry, well-ventilated area away from heat, sparks, open flames, and direct sunlight. Keep separate from strong oxidizers and acids. Ensure grounding/bonding for bulk transfers, and use flame-proof storage cabinets. Label clearly and inspect containers regularly for leaks or damage. |
| Shelf Life | Shelf life is typically 3 years unopened. Once opened, use within 1–2 years if stored tightly sealed. |
The 99.9% ACS isopropyl alcohol stream entering a wafer fabrication line is qualified primarily as a final displacement rinse after ultrapure water cleaning, because its low surface tension permits water removal from high-aspect-ratio structures and through-silicon vias without leaving water marks. On patterned wafers with critical dimensions below 10 nm, residual water pockets in STI trenches or TSV liners can generate silicate defects during subsequent plasma steps, and the water limit in the solvent is therefore maintained at ≤0.2% w/w by certificate of analysis, roughly 0.1% lower than the upper limit for typical technical-grade shipments. Working concentration in the rinse bath is either undiluted 99.9% isopropyl alcohol or a 70:30 v/v blend with ultrapure water, depending on the preceding etch residue load. Semiconductor-grade use falls under SEMI C41 for 2-propanol, with filtration at 0.2 µm through PTFE/PFA membranes and the tool located inside an ISO 14644-1 Class 5 cleanroom. The downstream process in a single-wafer spin rinser typically meters 0.5–1.0 L/min of 99.9% IPA onto a wafer rotating at 800–1,200 rpm; Marangoni dryers then deliver IPA vapour carried by nitrogen at 25–40 °C to displace water from the surface tension gradient. Production-scale failure modes observed on rinse dryers include droplet carryover when exhaust balance drifts and particle addition when push fittings are not solvent-welded. The solvent is flammable with a flammable range of 2.0–12.7 vol%, requiring NFPA 30 storage and Class I Division 2 electrical classification per NEC 500.5. Terminal product types include CMOS image sensors, DRAM and NAND wafers, GaN-on-SiC RF devices, and photomask reticles.
Solid-dosage manufacturing lines qualify 99.9% ACS IPA not as a formulation ingredient but as a cleaning agent for granulator bowls, tablet press turret contact parts, and fluid-bed dryer filters between batch campaigns. The water content below 0.2% w/w is critical where residual water would hydrolyze magnesium stearate or swell cross-linked povidone in a subsequent batch, generating a stability out-of-trend result rather than an immediate visible failure. Working solutions are prepared by mass as 70.0% IPA in purified water for surface sanitization with a 2–5 min contact time, followed by undiluted 99.9% IPA for final wipe-down of non-product-contact stainless steel surfaces, seals, and punch cavities at 25–150 mL/m². Compliance is derived from 21 CFR 211.67 for equipment cleaning, ICH Q3C residual solvent limits as a Class 3 solvent with a permitted daily exposure of 50 mg/day, and USP <1072> for disinfectant qualification. Because 70% IPA is not sporicidal, cleaning areas that process beta-lactam or cytotoxic actives are rotated with 6% hydrogen peroxide or peracetic acid; the IPA step is restricted to vegetative bioburden reduction and residue removal. In production-scale CIP systems, 99.9% IPA is dispensed through 0.2 µm filters into spray balls operated at 1.5–2.5 bar and 40–50 °C, then forced-air dried at 60 °C for 20–30 min. Cleaning validation swab recovery limits are calculated as 10% of the 50 mg/day PDE. Terminal finished products in this application are film-coated tablets, hard gelatin capsules, and prefilled syringe components.
In nail lacquer manufacturing, 99.9% ACS IPA functions as a true solvent for nitrocellulose and as a volatility modifier in a solvent blend alongside ethyl acetate and n-butyl acetate. The water content of technical-grade IPA above 0.3% w/w is sufficient to precipitate nitrocellulose from solution, producing a grainy film after application; therefore, the ACS water specification controls the critical failure mode for this downstream use. Formulation addition ratios of 5–12 wt% IPA reduce Brookfield viscosity at 25 °C from 1,200–1,800 mPa·s to 500–900 mPa·s when measured with an LV-DV2T spindle #4 at 30 rpm; above 15 wt% the dried film becomes brittle because solvent evaporation outpaces polymer coalescence. Under Regulation (EC) No 1223/2009, the cosmetic product safety report must address the solvent profile, while the closed-cup flash point per ASTM D56 is 12 °C, requiring EN 60079-10-1 zoning and nitrogen inerting below 7% oxygen during mixing. The downstream process uses an explosion-proof planetary mixer; nitrocellulose is pre-wetted with 99.9% IPA before plasticizers and co-solvents are added, which prevents dry-particle shear and deflagration risk. Batch-to-batch viscosity drift occurs when IPA is metered by volume rather than weight because density changes with water uptake, and drums that remain open at relative humidity above 60% absorb atmospheric water fast enough to shift final lacquer gloss within one shift. Terminal finished products are nail base coats, top coats, and anhydrous hair-resin sprays.
Unlike electronics-grade cleaning, the role of 99.9% ACS IPA in flexographic and gravure ink systems is not final-product purity but controlled solvent balance at the press-side ink sump, because water-based acrylic-urethane inks lose rewetting capacity once cylinder surface temperature exceeds 45 °C. In this use, IPA is metered into the ink sump at 2–6 wt% of supplied ink mass to lower dynamic surface tension from 30–32 mN/m to 25–27 mN/m, preventing pinholing on low-energy polyethylene film. For solvent-based polyamide/rosin systems, the let-down solvent blend may contain 10–20 wt% IPA, but press operators adjust in 1–2% increments while checking efflux viscosity to remain between 18–28 s on a Zahn #2 cup per ASTM D4212. If the printed package enters food contact, migration testing under Regulation (EC) No 1935/2004 and, for plastic substrates, Regulation (EC) No 10/2011 applies with an overall migration limit of 10 mg/dm²; paper and paperboard applications require FDA 21 CFR 176.170 compliance for the finished packaging material. The downstream process is run inside a closed doctor blade chamber with 40 L/min ink return at plate cylinder speeds of 150–300 m/min, followed by IR drying at 60–90 °C; operator exposure to IPA vapour is controlled below the OEL of 200 ppm TWA under ACGIH guidance. A typical field failure occurs when press crews substitute technical IPA containing 0.5% water into a nitrocellulose-based lamination ink, causing resin precipitation in the anilox cells and visible banding within 5,000 linear metres. Terminal product types are flexible film labels, paper cups, and folding cartons.
A 99.9% ACS IPA final wipe is specified for hydrophobic polycarbonate, polyurethane, and parylene-coated surfaces where aqueous detergents leave residues that alter adhesive bonding and electrical impedance. In cleanroom assembly, 70% IPA/water is applied first for bioburden reduction at a wet contact time of 60–120 s; then 99.9% IPA is used as the last solvent to remove non-polar process oils, silicone mold release, and finger oils without leaving conductive residues. The working ratio in ISO Class 7/8 assembly is 70:30 v/v IPA/water for the contact step and undiluted 99.9% for the final clean at 0.5–1.0 mL/100 cm², wiped until dry within 30 s. Procedures are executed under ISO 13485:2016 clause 7.5.2 and 21 CFR 820.70(e), with environmental bioburden monitored per ISO 14698-1. Gamma-sterilized polyester wipes saturated with 0.2 µm-filtered IPA are used with a 50% stroke overlap, and a 15–20 s evaporation window is enforced before adhesive bonding or coating. Operational limitations include that IPA does not remove endotoxin; depyrogenation requires dry heat per USP <1228>, and IPA has no sporicidal claim, so sterile barrier assembly areas rotate a sporicide on a weekly schedule. A batch-to-batch processing bottleneck observed on filling lines is residue on polycarbonate guide rails after 4–6 h of continuous operation; the corrective action is a wipe change every 200 parts rather than every shift. Terminal product types are intravascular catheters, ECG electrode patches, analytical cartridge manifolds, and sensor housings.
Prior to use as an HPLC mobile-phase component or GC headspace diluent, 99.9% ACS IPA is filtered through a 0.22 µm nylon membrane and degassed under vacuum at 25–30 kPa for 10–15 min, because dissolved oxygen shifts baseline noise in ultraviolet detection below 210 nm. The addition ratio in reversed-phase methods ranges from 1.0% v/v for protein-precipitation diluents to 30.0% v/v for hydrophobic analyte elution; in normal-phase methods the proportion may reach 50% v/v with heptane or hexane. The ACS Reagent Chemicals monograph for 2-propanol specifies assay ≥99.5%, water ≤0.2%, and low nonvolatile residue by titration and gravimetric methods, which is the upstream quality gate for trace analysis. Regulated laboratories verify solvent suitability under USP <467> residual solvent procedures and ICH Q3C Class 3 limits before committing a lot to method validation. The downstream process uses a 0.8–1.2 mL/min flow through PEEK tubing with UV detection at 210–254 nm; the optical cut-off of IPA near 205 nm limits its use in sub-210 nm methods. In production-scale dissolution testing, inline filtration with 0.45 µm PTFE syringes prevents particulate carryover from sample loops into the detector cell. Terminal deliverables are stability-indicating assay results, dissolution sample sets, and residual solvent determinations that are generated under data-integrity controls rather than sold as finished goods.
Competitive Isopropyl Alcohol 99.9% ACS Reagent Grade prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please contact us at +8618136850665 or mail to sales4@ascent-chem.com.
We will respond to you as soon as possible.
Tel: +8618136850665
Email: sales4@ascent-chem.com
Flexible payment, competitive price, premium service - Inquire now!
Isopropyl Alcohol 99.9% ACS Reagent Grade is a defined high-assay 2-propanol supplied as a clear, colorless, water-miscible liquid. The material identity is fixed by CAS 67-63-0, molecular formula C₃H₈O, molecular weight 60.10 g/mol, and the ACS Reagent Chemicals monograph for 2-propanol. Physical constants include boiling point 82.4°C, closed-cup flash point 11.7°C, density 0.785–0.788 g/cm³ at 20°C, and refractive index 1.3772 at 20°C. Assay is performed by gas chromatography with flame ionization detection on a bonded polyethylene glycol capillary column, 30 m × 0.25 mm × 0.25 µm, using split injection of 1 µL; the release limit for this product is not less than 99.9% on a water-free basis. That release is more restrictive than the ACS monograph minimum of 99.5%. The conventional model or catalog designation appears as “2-Propanol, ACS Reagent Grade, 99.9%”; supplier-specific stock-keeping unit codes differ only by container volume and closure type, not by formulation. No denaturant or fragrance is added.
Packaging is high-density polyethylene or fluorinated HDPE with a dry nitrogen headspace. Repeated opening at relative humidity above 60% can gradually raise water content toward the 0.2% monograph boundary; for water-sensitive work, the lot certificate value should be rechecked after prolonged opened-container storage using Karl Fischer titration.
The ACS reagent monograph controls the parameters most likely to interfere with quantitative residue-sensitive work. Table 1 summarizes the relevant boundaries for this grade. Lot certificates of analysis report actual values; the release targets below are not exhaustive and do not replace the receiving laboratory inspection.
| Parameter | Monograph limit | Release target for this product | Test technique |
|---|---|---|---|
| Assay by gas chromatography, water-free basis | ≥ 99.5% | ≥ 99.9% | GC-FID, polyethylene glycol capillary column |
| Water | ≤ 0.2% | ≤ 0.2% | Karl Fischer coulometric titration |
| Residue after evaporation | ≤ 0.001% | ≤ 0.001% | ACS evaporative residue method |
| Color, APHA/Pt-Co | ≤ 10 | ≤ 5 | ASTM D1209 platinum-cobalt comparator |
| Titrable acid or base | ≤ 0.0003 meq/g | ≤ 0.0001 meq/g | ACS titration |
| Refractive index n20/D | 1.3770–1.3780 | 1.3772 | Abbe refractometer at 20°C |
The ACS reagent monograph does not impose a far-UV absorbance cutoff at 205 nm or 210 nm. Therefore this material is not automatically equivalent to HPLC/UV-grade isopropanol, even when assay exceeds 99.9%. The ACS monograph also does not define trace-metal limits for semiconductor fabrication. Those applications require a separate low-metal or UV-transparent grade, or lot-specific ICP-MS and UV scan qualification before use.
In evaporative sample preparation and residue-sensitive extraction, the practical effect of the 0.001% residue boundary is cumulative. A 4 L volume evaporated on a rotary evaporator at 40–45°C and 250–400 mbar would contribute no more than 31 mg of solvent-derived nonvolatile matter at the monograph maximum. A 150 mL Soxhlet extraction charge contributes no more than 1.2 mg of nonvolatile residue. For histology dehydration sequences, water content below 0.2% supports the final nonaqueous alcohol step without introducing gross phase separation or excessive carryover water into xylene. For optical surface cleaning, the solution is applied to low-extractable polyester or α-cellulose wipes; after ambient evaporation, inspection under 100× microscopy is used to confirm the absence of visible haze or particle transfer.
Dilution to 70% v/v for surface decontamination is performed with purified water, not tap water, to preserve controlled ionic residue. The ACS grade controls the solvent-side nonvolatile residue and titrable acid/base, but it does not control endotoxin or microbial bioburden. Sterile filtration through a 0.22 µm membrane is required if the diluted solution enters an aseptic processing area.
The principal difference between grades is not always visible by simple refractive index or odor. The distinction is located in water, nonvolatile residue, and lot-specific analytical response. Table 2 compares representative specification philosophy. HPLC/UV limits vary by manufacturer and should be confirmed against the supplier certificate; published data for a universal HPLC specification is limited.
| Grade category | Assay, water-free | Water boundary | Nonvolatile residue boundary | Typical intended analytical use |
|---|---|---|---|---|
| Technical/industrial | commonly 98–99% | supplier-controlled, often not tightly limited | not specified | industrial thinning, general degreasing |
| ACS reagent | ≥ 99.5%, this product released at ≥ 99.9% | ≤ 0.2% | ≤ 0.001% | wet-chemistry preparation, extraction, residue-sensitive rinsing |
| USP/NF | ≥ 99.0% | monograph water test, often ≤ 0.5% | monograph nonvolatile residue test | pharmaceutical compounding where an alcohol is specified |
| HPLC/UV | ≥ 99.9% | ≤ 0.05% | ≤ 0.0005% | UV-transparent mobile phases, gradient LC at 205–210 nm |
Storage and transfer are governed by flammable-liquid classification under GHS H225. The closed-cup flash point is 11.7°C, vapor pressure at 20°C is 4.4 kPa, and the flammable range in air is approximately 2.0 vol% to 12.7 vol%. Containers are kept in a ventilated flammable-storage cabinet below 25°C, away from ignition sources. Vapors are denser than air and can travel along bench surfaces to distant ignition points. The material should not be combined in closed vessels with strong oxidizers, acid chlorides, chromic acid, sodium hypochlorite, or strong mineral acids because oxidation products and pressure rise can occur. Distillation of aged or recycled material should be preceded by iodometric or test-strip peroxide checks. For pharmaceutical manufacturing governed by 21 CFR 211, ACS reagent grade is not automatically equivalent to USP/NF material; it must be qualified by the receiving site against the pharmacopeial monograph before drug-product use. For sub-part-per-billion ion analysis, semiconductor-grade or low-metal IPA is required because ACS reagent grade alone does not control particle shedding or extractable metals to below 1 µg/L.
